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Cell Line Development for Biotherapeutics

Enhancing cell line development workflows to enable successful IND submissions.

We accelerate cell line development workflows from initial discovery to scale-up and manufacturing of new biological therapies

From single-cell cloning and colony outgrowth to the establishment of a master cell bank, cell line development technologies from Advanced Instruments streamline the collection of evidence for credible IND submissions.

Streamlining Key Steps

When you’re bringing a biotherapeutic to market, finding the optimal cell line and ensuring clonality are critical for success, whether the cell line produces the biotherapeutic or is the biotherapeutic.

At Advanced Instruments, we’ve identified critical bottlenecks in the cell line development workflow and created unique instruments and reagents that save time and advance your program while efficiently collecting key IND-enabling data.

Efficiently Ensuring Clonality

Move beyond limiting dilution methods to gentle, imaging-assured single cell seeding with the SolentimVerified In-Situ Plate Seeding (VIPS™)instrument. Combining low-pressure single cell seeding with whole-well imaging, VIPS simplifies cell line development workflows while gathering credible data for IND submission.

Alternatively, you can image individual plates with the stand-aloneSolentim Cell Metric®instrument. The Cell Metric captures and records whole well images at day 0 with daily imaging thereafter, delivering a clonality report that defines best practice for master cell bank production.

Accelerating Ranking and Selection of High Producing Clones

Make informed decisions faster and more securely when you combine the SolentimICON™withSTUDIUS™.

ICON is a single, multifunctional instrument that enables the triage of clones via low volume titer and viable cell assays. ICON can integrate with STUDIUS for complete analysis of cell line development data.

Demonstrating monoclonality has never been more reliable and straightforward. No more ambiguity, no more ghost cells. Both our clients and our own scientists are very pleased with the data the VIPS instrument generates

Ferenc Boldog, Director of Cell Line Development ATUM, San Francisco

Popular Educational Resources

Learn more about how our technologies enhance your cell line development workflow by checking out our educational resources below

Associated Products

Solentim VIPS™

Gentle, efficient single cell seeding with imaging to confirm clonality

Solentim Cell Metric®

Efficiently assure clonality with high contrast imaging

Solentim ICON™

Maximize productivity by assessing titer and viability with a single instrument

Solentim STUDIUS™

Data management for the highest level of consistency across the CLD workflow

Next Generation Cell Culture Growth Supplements

Animal component-free cell culture supplements for CHO and HEK cells

Clinitrol™ 290 Reference Solution

Intended for use in evaluating the performance of your osmometer



Get the best performance from your osmometers and cell line development instruments from the people who designed and built them. We provide a range of services and service plans to meet the different needs of our customers.

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