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Because oglio manufacturing is an emerging field, it comes with a number of development and application challenges:

  • Delivery of RNAs across the lipid bilayer and into cells
  • 免疫原性一次
  • High rates of degradation of oligos by plasma and tissues

Drug delivery into the target cells requires the proper osmotic pressure, similar to the parameters around viral transfection in vector development. The optimal osmolality of the delivery complex (e.g. mRNA:PEI) should be determined and monitored during this process. This specification will provide repeatable successful delivery of the drug.


Current Applications of Osmolality in Oligonucleotide Manufacturing and Development

As the field of oligonucleotides continues to develop the uses of osmolality continue to grow. Below are some of the current uses for osmolality testing in this field:

The system has excellent accuracy and precision, even between different analysts. The great thing about the XT model is that it can measure a broad range of sample osmolality to cover all of our sample needs.

Will Heaton, DiscGenics

Popular Educational Resources

学到更多about how our osmometers can be utilized to optimize your workflows by checking out our educational resources below


Impact Of Osmolality During The AAV Manufacturing Workflow


8 Ways That Osmolality Testing Improves Cell and Gene Therapy Processing


渗透压Measurement of Lentiviral Vectors for Cell and Gene Therapy

Associated Products

OSMOTECH®XT Single-Sample Micro-Osmometer

Best-in-class osmolality performance, designed for the toughest samples

OSMOTECH®PRO Multi-Sample Micro-Osmometer




Get the best performance from your osmometer from the people who designed and built it. We provide a range of services and service plans to meet the different needs of our customers.