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Reagents & Controls

At Advanced Instruments, our commitment to your lab’s quality and productivity translates into more than just building reliable, high-performance instruments. It extends to supporting your efforts to generate results you can trust with our line of trusted reagents and controls.

Our portfolio includes cell growth reagents designed to enhance cell growth at different stages of cell line development for accelerated workflows. Our iPSC matrix supports iPSC growth in single cell seeding workflows while maintaining pluripotency.

Our family of calibration and control reagents can help verify instrument performance, ensure linearity, and provide relevant reference controls, efficiently and accurately while ensuring traceability to NIST standards, patient integrity or meet internal quality metrics.

Explore All Reagents & Controls


In the search for high-value cells, growth conditions can be optimized to support early growth conditions. The Insti Reagents products are proprietary animal component-free cell culture supplements for CHO and HEK cells which confer major growth and survival advantages within cell line development.

Solentim MatriClone™ IPSC Matrices


Biotech Calibrators & Controls

Our line of biotech calibrators and controls are used on osmometers across bioprocessing workflows. These products are designed to ensure osmometers’ optimal performance and accuracy of test results across instrument reportable range.

Protinol™ and Renol™ Osmolality Controls

We’ve designed our Protinol and Renol controls specifically for our osmometers to ensure optimal performance and accurate results. These controls help laboratories meet CAP and CLIA guidelines. Protinol is a line of protein-based serum osmometer control solutions intended for use in evaluating the performance of your osmometer in clinical laboratories testing of human serum samples. Renol™ is a line of urine osmolality control solutions that are intended for use in evaluating the performance of your osmometer in clinical laboratories testing human urine.

校准Standards For Osmometers

A wide range of Advanced Instruments Calibration Standards are available and designed to accurately calibrate our full line of advanced osmometers. Specific calibration levels are designated for each instrument. In addition, the calibration standards can be used to check the performance of your osmometer and test methods.

Clinitrol 290 Reference Solution

Clinitrol is a true instrument reference solution and provides results that approximate the osmolality of normal body fluids and physiological solutions. Use Clinitrol to verify system calibration and as a daily system check to strengthen your laboratory’s quality control program.


The Osmolality Linearity Set is designed to help laboratories easily monitor osmometer performance specifications for verifying the reportable range of a laboratory method. The package contains two sets of 5 mL ampules with assigned values of 100, 500, 900, 1500, and 2000 mOsm/kg H2O.

CryoLine™ Cryoscope Supplies

The Advanced Instruments CryoLine products are standards and laboratory supplies specifically designed for use with Advanced Instruments cryoscopes.

What is Instrument Calibration?

One of the primary processes used to maintain instrument accuracy, calibration is the process of configuring an instrument to provide a result for a sample within an acceptable range. Eliminating or minimizing factors that cause inaccurate measurements is a fundamental aspect of instrumentation design.

What does the calibration process entail?

校准process generally involves using the instrument to test samples of known values called “calibrators.” The results are used to establish a relationship between the measurement technique used by the instrument and the known values. The process “teaches” the instrument to produce results that are more accurate than those that would occur otherwise. The instrument can then provide more accurate results when samples of unknown values are tested within normal usage of the product.

Why should I use manufacturer-recommended calibrators for QC?

It is important to use calibrators that are formulated to tight tolerance specifications by a reputable manufacturer. There is a tolerance associated with formulating a calibrator/control due to normal variations in the instrumentation and quality control processes. This tolerance can affect the mean value obtained when using the calibrator.

Can’t I just use any calibrator to calibrate my osmometer?

It is important to closely follow the instructions for use during calibration. If the wrong calibrator is selected, the error values will “teach” the instrument incorrectly, and produce significant errors over the entire operating range. Many instruments have software diagnostics that alert the operator if the calibrators are tested in the incorrect order, while still accepting one or more calibrators of the wrong value without detecting the operator’s error.


In clinical labs, CAP and CLIA require verification of your osmometer’s analytical measurement range (AMR) before introducing new instruments in your lab and every 6 months for instruments placed in service. Advanced Instruments provides linearity reporting services; simply submit your data using our Osmolality Linearity Set and we’ll provide an audit-ready report.