
Vaccine Production using Mammalian Cells
重组蛋白质疫苗的工业生产需要稳定的细胞系。确保细胞系来自单个细胞,'克隆衍生',可以导致更强大的细胞系。目前产生疫苗的永生细胞系的最佳实践是进行单细胞分离。在这种情况下,细胞系开发的速度尤为重要,以便快速打击潜在的大流行。通过Solentim工作流程,从转染到细胞库的时间可以在短短12周内实现。
Education
同渗重摩测试是需要确保final vaccine product is safe for administration. The osmolality must be within a physiological range to be introduced in human tissues. There is also evidence that injectable formulations with high osmolality may cause pain at the site of injection.
疫苗are derived from a variety of sources, both living and synthetic, meaning a variety of bioproduction workflows are required. These workflows include some common use cases for osmolality testing such as cell culture monitoring, buffer media preparation, and final QC.
With the OsmoTECH® portfolio of osmometer you can always ensure product quality throughout every step of vaccine manufacturing.

Accelerating The Timeline to Develop mRNA Based Vaccines
mRNA can be complexed with different agents (e.g. PEI) for delivery within the body. Osmolality impacts the stability of the complex of viral models and the ability to penetrate the target cell membrane.


对于vips,这里有很少的媒体,可以很容易地找到细胞并证明细胞是克隆的卫生当局。
Thomas Kelly, Scientist at Janssen R&D LLC
Popular Educational Resources
了解有关如何利用我们的技术如何帮助加速基于细胞的疫苗生产通过查看以下教育资源

Webinar
Warp speed RNA vaccine development and manufacturing in the Covid Age: How can we mass produce high-quality vaccines faster and cheaper?
Associated Products

Osmotech.®XT Single-Sample Micro-Osmometer
Best-in-class osmolality performance, designed for the toughest samples



Solentim VIPS™
High efficiency, high viability single cell cloning for Cell Line Development and Cell Therapy

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