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Vaccine Production using Mammalian Cells



同渗重摩测试是需要确保final vaccine product is safe for administration. The osmolality must be within a physiological range to be introduced in human tissues. There is also evidence that injectable formulations with high osmolality may cause pain at the site of injection.

疫苗are derived from a variety of sources, both living and synthetic, meaning a variety of bioproduction workflows are required. These workflows include some common use cases for osmolality testing such as cell culture monitoring, buffer media preparation, and final QC.

With the OsmoTECH® portfolio of osmometer you can always ensure product quality throughout every step of vaccine manufacturing.

Accelerating The Timeline to Develop mRNA Based Vaccines

mRNA can be complexed with different agents (e.g. PEI) for delivery within the body. Osmolality impacts the stability of the complex of viral models and the ability to penetrate the target cell membrane.


Thomas Kelly, Scientist at Janssen R&D LLC

Popular Educational Resources



Practical Use of Osmolality Measurement in Vaccine Formulation Development


Warp speed RNA vaccine development and manufacturing in the Covid Age: How can we mass produce high-quality vaccines faster and cheaper?


Reliable Osmolality Testing of High Concentration mAb Formulations

Associated Products

Osmotech.®XT Single-Sample Micro-Osmometer

Best-in-class osmolality performance, designed for the toughest samples

Osmotech.®PRO Multi-Sample Micro-Osmometer


Solentim Cell Metric®


Solentim VIPS™

High efficiency, high viability single cell cloning for Cell Line Development and Cell Therapy



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